13-Night South America Luxury Itinerary

Desert becomes ice. Ice gives way to vineyards. Vineyards turn to rainforest, before the journey reaches the sea.

Across Biomes is an expansive journey through five distinctly different South American landscapes, connecting Awasi Atacama, Patagonia, Mendoza, Iguazú and Santa Catarina across Chile, Argentina and Brazil.

Spend 13 nights across five Awasi lodges, with an additional connecting night in Santiago, traveling from the vastness of the Atacama Desert to the glaciers of Patagonia, the vineyards of Mendoza, the subtropical forest surrounding Iguazú Falls and the Atlantic coast of Santa Catarina.

Throughout the journey, each villa is paired with a private guide and dedicated 4WD vehicle. Rather than following a fixed group itinerary, days are shaped around your interests, pace and the landscape itself.

The journey begins in one of the driest places on Earth.

Fly from Santiago to Calama, where your Awasi guide meets you for the private journey into San Pedro de Atacama. As the road continues into the desert, the landscape strips itself back: immense horizons, sculpted rock and the Andes rising in the distance.

Over three nights, explore the Atacama from multiple perspectives.

Walk through Garganta del Diablo, a canyon carved into the landscape near Catarpe, before venturing among the towering cacti of Guatín. Continue on horseback through Valle de Marte, crossing rust-colored earth and wind-sculpted terrain.

Another day begins high in the Andes at El Tatio, where geysers and fumaroles rise through the cold morning air. After sunset, look upward. The Atacama’s altitude, dry climate and dark skies create extraordinary conditions for astronomical observation.

Before leaving, discover Rainbow Valley, where minerals have painted bands of color across the desert hills.
From here, return to Santiago for an overnight stay before traveling south.

Leave Patagonia behind and travel north into Argentina’s wine country.

Mendoza offers a natural change of pace after three days of Patagonian exploration. Mountains remain on the horizon, but vineyards now stretch across the landscape beneath them.

Spend a full day discovering the region through private wine tastings before turning to another distinctly Argentine tradition with an evening tango performance.

The following day begins around the table with a cooking experience inspired by regional ingredients and flavors. Later, travel into Luján de Cuyo on horseback, exploring the vineyard country at the foot of the Andes.

Two nights provide a concentrated Mendoza itinerary centered on wine, food and the landscape that produces both.

After desert, mountains, vineyards and rainforest, the final landscape is the coast.

Fly from Foz do Iguaçu to Florianópolis and continue to Awasi Santa Catarina for three final nights beside the Atlantic.

Take to the water by kayak, venture farther offshore on a deep-sea fishing experience, or explore on foot with a hike at Morro do Pico before returning to the coast for stand-up paddleboarding.

The final days are intentionally different from the beginning of the journey. After nearly two weeks of exploration, there is room for the pace to soften.

The desert feels far away now.

The ocean is in front of you.

Across Biomes covers an extraordinary amount of ground without turning the experience into a conventional tour.

At every Awasi lodge, each villa is paired with a private guide and dedicated 4WD. Daily excursions are tailor-made and can be adjusted throughout the stay according to interests, activity level, arrival times and weather.

Regional flights connect the five destinations, with private airport transfers arranged along the route.

The result is a two-week South America itinerary that feels both expansive and deeply personal: five landscapes, three countries and one continuous journey through the continent.